Combining Bioinformatics and Biophysics to Understand Protein-Protein and Protein-Ligand Interactions
نویسندگان
چکیده
منابع مشابه
Correction to 'Biophysics of protein evolution and evolutionary protein biophysics'.
References http://rsif.royalsocietypublishing.org/content/11/100/20140419.full.html#ref-list-1 This article cites 435 articles, 131 of which can be accessed free Subject collections (313 articles) computational biology (354 articles) biophysics (49 articles) bioinformatics Articles on similar topics can be found in the following collections Email alerting service here right-hand corner...
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Background: Protein-protein interactions do not provide any direct information regarding the domains within the proteins that mediate the interactions. The majority of proteins are multi domain proteins and the interaction between them is often defined by the pairs of their domains. Most of the former studies focus only on interacting domain pairs. However they do not consider the in...
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In order to maintain cellular homeostasis, cellular proteins coexist in complex and variable molecular assemblies. Therefore, understanding of major physiological processes at molecular level is based on analysis of protein-protein interaction networks. Firstly, composition of the molecular assembly has to be qualitatively analyzed. In the next step, quantitative bio-chemical properties of the ...
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v CHAPTER 1 : GENERAL INTRODUCTION 1 Thesis Organization 5 References 9 CHAPTER 2: DISTINCTIONS MADE IN THE PROTEIN RECOGNITION OF CARBOHYDRATES 14 Abstract 14 Introduction 15 Discussion 19 Conclusion 24 References 26 CHAPTER 3: SPECIFIC EMPIRICAL FREE ENERGY FUNCTION FOR AUTOMATED DOCKING OF CARBOHYDRATES TO PROTEINS 34 Abstract 34 Introduction 35 Methods 37 Results and Discussion 42 Conclusio...
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The study of molecular evolution at the level of protein-coding genes often entails comparing large datasets of sequences to infer their evolutionary relationships. Despite the importance of a protein's structure and conformational dynamics to its function and thus its fitness, common phylogenetic methods embody minimal biophysical knowledge of proteins. To underscore the biophysical constraint...
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ژورنال
عنوان ژورنال: The Scientific World JOURNAL
سال: 2002
ISSN: 1537-744X
DOI: 10.1100/tsw.2002.22